Plos one ep 67

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View Article Google Scholar Bland-Altman plot is shown for Ki67 expression on whole sections and core needle biopsies. Some studies on Ki67 have shown good concordance between CNB and WS tissues [36] — [39]whereas others have found only fair to moderate agreement [25][40][41]. Supplementary tables. Breast Cancer: 1—8. Good to excellent agreement has been demonstrated for hormone receptors and HER2 status, whereas histologic grade has shown only modest concordance, mainly due to underestimation of mitotic count on CNB specimens [31] — [35].


  • Mice were insufflated with EP67 as in Figure 1. BAL cells were isolated either two hours or one day later, then stained with fluorescent antibodies and analysed.

    Epithelial crypt cells of normal small intestine expressed neither EP-receptor mRNA nor analysis with anti-Ki67 antibody to identify proliferating cells. Figure 1. X-axis is time in days following EP67 insufflation. A. Absolute cell number following EP67 insufflation. B. Subpopulations of BAL cells as % of BAL cell population.
    The remaining 2 patients were disease free after initial radical surgery, and received systemic chemotherapy after disease recurrence was observed.

    BAL cell analysis one day after EP67 insufflation. View Article Google Scholar 2. All patients provided full informed consent before repeating histological assessment. Observer agreement for Ki67 counts.

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    Analyses were performed using the SPSS statistical package, version Mice were insufflated with EP67 as in Figure 1.

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    Plos one ep 67
    Table 3.

    Thirty-eight patients Variability of Ki67 labeling index in multiple neuroendocrine tumors specimens over the course of the disease. Total cell number of individual BAL cell subpopulations.

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    All slides were examined and scored by one pathologist GKblinded to patient characteristics and outcome. Due to these reasons, a larger multicenter study planned with a prospective design is needed to better define the role of histological re-assessment at time of PD in the follow-up algorithms of patients with EP-NENs.

    PLoS ONE 14(7): e. data is with ± 30% relatively low but they are quite accurate [67].

    We have developed a response-selective agonist of human C5a, termed EP67, which retains the immunoenhancing activity of C5a at the.

    MammaPrint high-risk tumors were also high-risk by EP score. Fig 1. Comparison of proliferative index (Ki67) with EP score (A) and EPclin score (B).
    Results Clinico-pathologic characteristics of the patients In the current study, median tumor size was 15 mm range 3— mm.

    The American journal of surgical pathology 11— Adjuvant therapy was decided according to tumor size, histologic grade, hormone receptor status and nodal status. Breast 6: — Interestingly, the Ki67 change mainly occurred in pancreatic NENs, in which a statistically different G grading distribution was observed at PD in comparison with initial assessment, a figure that was not observed in the non-pancreatic NENs setting Table 2.

    Figure S4.

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    Metastatic and locally advanced pancreatic endocrine carcinomas: analysis of factors associated with disease progression.

    For each category, the number of events is given followed by the number of patients. The Journal of pathology — TMA samples with fewer than tumor cells were considered not interpretable.

    In fact, international guidelines [ 513 ] suggest to use somatostatin analogs as first line therapy in G1 and G2 NENs with relatively low Ki67, whereas more aggressive treatments i.

    Overall, they were bioptic or surgical specimens in 33 Appl Immunohistochem Mol Morphol —

    There is a significant difference in tumor cell proliferation by Ki67 across PLoS ONE 9(11): e .

    Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, et al. One day later, groups were insufflated with either EP67 ( µg/mouse) or saline. Mice were sacrificed when weight loss reached 30% of starting body weight. Ki LI of early lung adenocarcinoma presenting GGO can be predicted by radiologic parameters PLoS ONE 10(6): e Francisco JS, Moraes HP, and Dias EP.
    Supplementary tables.

    Univariate survival analysis of Ki67 in CNB sections showed all examined cut-points above the 40 th percentile to be prognostic. Box plots of tumor cell proliferation by Ki67 expression according to breast cancer molecular subgroups in different specimen categories. Analyses were performed using the SPSS statistical package, version Cancer Epidemiol Biomarkers Prev — After the suggestion of Ki67 as a predictive marker for adjuvant chemotherapy, observer variation and methodological issues have been increasingly discussed [8][16].

    Since prognostic studies have indicated that disease progression is best predicted by Ki67 counted in hot-spot areas, a similar approach should probably be considered for predictive purposes.

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    Plos one ep 67
    Ki67 counts in relation to different specimen types The following results are based upon hot-spot counts, unless otherwise is stated.

    Ann Oncol — For continuous variables, the proportional hazard assumptions were also assessed by studying the graphs of Schoenfelds residuals. Percentage of NK1. Breast 6: —

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